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BIRMINGHAM, Ala. — After a demanding shift stocking coffee beans at grocery stores around Birmingham, 27-year-old Sarah Stewart retreats to a familiar spot. She sits comfortably in her mother’s office chair, gently rests a pair of virtual reality goggles over her eyes, and steps into an immersive digital realm. On this particular afternoon, she selects…
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Mount Sinai researchers have unveiled significant new insights into the mechanisms by which APOE4—the most potent genetic risk factor for Alzheimer’s disease—triggers damage within the human brain. According to two landmark studies published in the journals Cell and Cell Stem Cell, this gene does far more than predispose individuals to neurodegeneration; it actively degrades the…
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For decades, the prevailing consensus in neurology was that the devastating neurodegeneration seen in Alzheimer’s disease and related conditions was primarily an internal affair—a localized war occurring behind the formidable barricades of the blood-brain barrier. Scientists focused their efforts on the internal buildup of toxic proteins, such as amyloid plaques and tau tangles, viewing the…
